Stat5a Polyclonal Antibody, 50ul[BT-AP08639] Polyclonal Antibody Preparation IL5 encodes a cytokine that

IL5 encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils

Alternatively spliced transcript variants encoding distinct isoforms have been reported

The three 5' exons reside in the pseudoautosomal region and the remaining exons within the X-specific end

has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs

and is specifically localized to epithelial cells in skin

Stat5a Polyclonal Antibody, 50ul[BT-AP08639] Polyclonal Antibody Preparation IL5 encodes a cytokine thatStat5 is activated in response to a wide variety of ligands including IL 2, GM CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL 3, which suggests its involvement in angiogenesis and cell motility.